Real Sex explores human sexuality, from the latest sexual fads to casual sex festivals and home production of pornographic movies. The show typically explores three to four topics each episode. Segments are separated by street interviews with random people, relating to the episode's topics.
The last Real Sex episode aired in 2009. Older episodes as well as "best-of" episodes are frequently re-aired during late nights on HBO.
It spawned a spin-off series called Pornucopia.