Special guest star: William Shatner.
The Police Squad department is sent to investigate a bombing at the courthouse. The main suspect is Eddie Casales (Spencer Milligan
), a bomber who was sent to jail by the victims killed in the explosion. Following the attack on the courthouse, the assistant DA who prosecuted Casales is killed with a bomb hidden in is car. All evidence points to Casales, but Frank thinks it is a setup.
Every episode had a special guest star who was introduced in the opening credits, but then met a grisly death and made no further appearance in the episode.
Another recurring gag on the opening sequence of the show was an on-screen graphic listing the title of the episode, with an announcer's voiceover intentionally giving a different title for the episode.
In the list below the titles that appeared on the screen are given, followed by the announcer's title in parentheses. Another running gag is where Frank would offer a cigarette, he would say "Cigarette?" while holding out a carton, only for the person to reply "yes, it is". Also in each episode Frank would run his car into trash cans, with how many being the current episode number (ie runs into 3 trashcans on episode 3). The last running gag would be at the end of each episode, the characters would freeze in place as the credits roll, however the actions around them would continue to move.